Methotrexate

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Methotrexate (green) complexed into the active site of DHFR (blue)

Methotrexate (rINN) (), abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate began to replace the more toxic antifolate aminopterin starting in the 1950s. The drug was developed by Yellapragada Subbarao.

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National Rheumatoid Arthritis Society (NRAS) National Rheumatoid Arthritis Society (NRAS) www.nras.org.uk/.../methotrexate_in_rheumatoid_arthritis.aspx - Web

Chembank Chembank chembank.med.harvard.edu/.../display.html?compound_id=464&mode=history - Web

Methotrexate Methotrexate www.nlm.nih.gov/medlineplus/druginfo/meds/a682019.html - Web

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Gallery for «Methotrexate»

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Methotrexate Injection Methotrexate Injection www.nlm.nih.gov/medlineplus/druginfo/meds/a682018.html - Web

Patient Education - Methotrexate Patient Education - Methotrexate www.rheumatology.org/.../methotrexate.asp - Web

U.S. National Library of Medicine: Drug Informatio... U.S. National Library of Medicine: Drug Information Portal - Methotrexate druginfo.nlm.nih.gov/drugportal/dpdirect.jsp?name=Methotrexate - Web

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