DNA microarray
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 Two Affymetrix chips. A match is shown at bottom left for size comparison. |
A DNA microarray (also commonly known as DNA chip or biochip) is a collection of microscopic DNA spots attached to a solid surface. Scientists use DNA microarrays to measure the expression levels of large numbers of genes simultaneously or to genotype multiple regions of a genome. Each DNA spot contains picomoles (10−12 moles) of a specific DNA sequence, known as probes (or reporters or oligos). These can be a short section of a gene or other DNA element that are used to hybridize a cDNA or cRNA (also called anti-sense RNA) sample (called target) under high-stringency conditions. Probe-target hybridization is usually detected and quantified by detection of fluorophore-, silver-, or chemiluminescence-labeled targets to determine relative abundance of nucleic acid sequences in the target.
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- Related: Cyanine, Full Genome Sequencing, Gene chip analysis, Microfluidics, Pathogenomics, Systems biology
| PLoS Biology Primer: Microarray Analysis PLoS Biology Primer: Microarray Analysis www.plosbiology.org/.../info%3Adoi%2F10.1371%2Fjournal.pbio.0000015 - Web |
| Rundown of microarray technology Rundown of microarray technology www.genome.gov/page.cfm?pageID=10000533 - Web |
| ArrayMining.net ArrayMining.net www.arraymining.net - Web |
Gallery for «DNA microarray»
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| CLASSIFI CLASSIFI pathcuric1.swmed.edu/pathdb/classifi.html - Web |
| Microarray - How does it work? Microarray - How does it work? www.unsolvedmysteries.oregonstate.edu/microarray_07 - Web |
| What Are DNA Microarrays What Are DNA Microarrays www.bioinformaticstutorials.com/?p=8 - Web |
| PNAS Commentary: Discovery of Principles of Nature... PNAS Commentary: Discovery of Principles of Nature from Mathematical Modeling of DNA Microarray Data www.pnas.org/content/103/44/16063.extract - Web |
| Microarray Protocols Microarray Protocols www.lab-manual.com/lm_107.htm - Web |
